Since the description of the RhD antigen by Levine and Stetson in 1939, more than 40 other Rh antigen complexes have been identified. With the exception of the C, c, E and e and perhaps C^w, few of these antigens or their corresponding antibodies are controlled by a series of closely linked loci on chromosome 1, the genetic contribution from each parent being inherited as a haplotype e.g. Cde, cDE etc. Used separately, anti-Rh blood grouping reagents will indicate whether an individual expresses the corresponding antigen – an essential procedure in the determination of antibody specificity and selection of blood for transfusion of patients with Rh antibodies.

The Biorex Diagnostics monoclonal IgM Anti- Rh blood grouping reagent contains human monoclonal antibodies diluted with sodium chloride, bovine albumin and macromolecular potentiators. This reagent is supplied ready for use and does not require any further dilution or addition.